Manuscript collections are historically significant papers and records created by individuals, businesses, and other organizations throughout the course of their activities. Types of materials include letters, diaries, legislator's papers, business records, records of social clubs, and many other type of materials.

• John W. Beecroft Papers (Personal and Business Correspondence)
• • Book Publishing
  • Russian Propaganda
• Federal Government Special Collections
• • Federal Arts Project Fine Art Prints
  • U.S. Army Information Branch WW II Newsmaps
• Jim Dan Hill Personal Papers (WW II, National Guard)
• Mary Pulford Collection (Pow-Wow Photographs)
• George N. Ross Letters (California Goldrush)
• Gordon Levine Papers (Transportation)
• Patrick Dorin Papers (Transportation)
• Joseph T. Mengel, Jr. Papers (Geology)